Antoine Dupont will captain France in their opening round fixture with Wales after missing last season's tournament due to his Olympic Sevens commitments which ended in him winning a gold medal.
Scrum-half Dupont, 28, is partnered at half-back by Toulouse team-mate Romain Ntamack in five changes from Les Bleus' last game, November's win over Argentina.
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Ntamack, 25, makes his first Test appearance since August 2023 having suffered two long-term injuries.
France have won 15 out of 19 Six Nations games with Dupont and Ntamack starting, including the run to the 2022 Grand Slam title.
"They play often together at their club," coach Fabien Galthie said.
"It's an 'old-new' half-back partnership with a lot of experience despite their youth," he added.
Among the other changes are Theo Attissogbe coming in on the right wing owing to an injury to Damian Penaud.
On the opposite flank is Penaud's fellow Bordeaux-Begles flyer in Louis Bielle-Biarrey, who has scored 16 tries for club and country this season.
In midfield, Pierre-Louis Barassi replaces the injured Gael Fickou and last year's Six Nations skipper Gregory Alldritt is at No 8 instead of Ollivon. Alexandre Roumat comes in for Flament at lock.
For Wales, experienced backs Josh Adams and Liam Williams return as Warren Gatland's men bid to end a 12-match losing streak.
The return of wing Adams and full-back Williams, who both missed large chunks of 2024, is a major boost for Wales, who finished bottom of the table in last year's tournament.
Exeter lock Dafydd Jenkins, who captained the side in the 2024 Six Nations, is also back in the team after undergoing knee and shoulder surgery.
Former England prop Henry Thomas will make his first Wales start in Paris. The Scarlets tighthead has won four caps as a replacement since switching allegiance to Wales in 2023.
Wales coach Gatland has selected a back-row of Aaron Wainwright at No 8 alongside James Botham and captain Jac Morgan.
Saracens centre Nick Tompkins is recalled, partnering Owen Watkin in midfield.
Cardiff's Ben Thomas fills the fly-half role with uncapped Ospreys No 10 Dan Edwards on the bench.
France (15-1): Thomas Ramos; Theo Attissogbe, Pierre-Louis Barassi, Yoram Moefana, Louis Bielle-Biarrey; Romain Ntamack, Antoine Dupont (capt); Gregory Alldritt, Paul Boudehent, Francois Cros; Emmanuel Meafou, Alexandre Roumant; Uini Atonio, Peato Mauvaka, Jean-Baptiste Gros
Replacements: Julien Marchand, Cyril Baille, Georges-Henri Colombe, Hugo Auradou, Mickael Guillard, Oscar Jegou, Nolann Le Garrec, Emilien Gailleton
Wales (15-1): Liam Williams; Tom Rogers, Nick Tompkins, Owen Watkin, Josh Adams; Ben Thomas, Tomos Williams; Aaron Wainwright, Jac Morgan (capt), James Botham; Dafydd Jenkins, Will Rowlands; Henry Thomas, Evan Lloyd, Gareth Thomas
Replacements: Elliot Dee, Nicky Smith, Keiron Assiratti, Freddie Thomas, Tommy Reffell, Rhodri Williams, Dan Edwards, Blair Murray
