The Queensland Reds will chase a Fiji breakthrough without in-form flyhalf Carter Gordon and their captain and Wallabies star Fraser McReight.
Prop Zane Nonggorr has also been rested for the Drua fixture in Lautoka, where Jock Campbell will join Chris Latham as a 100-game fullback for the Reds.
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Campbell has been in scintillating form to begin the season and will have Hunter Paisami in the midfield on his injury return alongside the in-form Isaac Henry and Filipo Daugunu.
The 30-year-old is reluctant to dwell on his rugby journey that saw him playing second XV rugby at school and work his way through the grades in club rugby before winning a Test debut in 2022.
"It's cool, other people think my story's cooler than myself," Campbell said of his unique journey to join the likes of Wallabies greats Tim Horan, John Eales and Latham in the Reds' 100 club.
"It sounds a little bit ridiculous to me. (It's) something I'm proud of and I guess hasn't quite hit me yet.
"I'm feeling good, the body's feeling the best it has in a little while and (we're winning) some tight games we might not have won in the past."
Ben Volavola has been added to the bench for a likely Reds debut, while playmaker Harry McLaughlin-Phillips will wear the No.10 as Gordon is managed and Tom Lynagh remains on the injured list.
Nick Bloomfield will pack into the front row with Wallabies prop Nonggorr missing, while John Bryant will replace McReight.
"It's part of the process of having regeneration weeks for players. Fraser, Carter and Zane will miss this game," Reds head coach Les Kiss said.
"This creates opportunities for prop Nick Bloomfield and backrower John Bryant, who have both played in our three Development games. Harry McLaughlin-Phillips has played for us in every game this season and will start this one at flyhalf."
The Reds have won three straight games but have never tasted success in Fiji, then have a testing trip to Wellington to face the Hurricanes a week later.
REDS (1-15): Aidan Ross, Josh Nasser, Nick Bloomfield, Seru Uru, Lukhan Salakaia-Loto, Joe Brial, John Bryant, Harry Wilson (c), Kalani Thomas, Harry McLaughlin-Phillips, Tim Ryan, Hunter Paisami, Isaac Henry, Filipo Daugunu, Jock Campbell
Replacements: Richie Asiata, George Blake, Jeffery Toomaga-Allen, Hamish Muller, Vaiuta Latu, Louis Werchon, Ben Volavola, Treyvon Pritchard
